CYHEXATIN First draft prepared
نویسنده
چکیده
Explanation.................................................................................................. 149 Evaluation for acceptable daily intake......................................................... 150 Biochemical aspects........................................................................... 150 Absorption, distribution and excretion ....................................... 150 Biotransformation....................................................................... 155 Toxicological studies ......................................................................... 156 Acute toxicity ............................................................................. 156 Lethal doses......................................................................... 156 Dermal and ocular irritation and dermal sensitization......... 156 Studies of toxicity with repeated doses ............................... 159 Long-term studies of toxicity and carcinogenicity ..................... 163 Genotoxicity ............................................................................... 167 Reproductive toxicity ................................................................. 169 Oneand two-generation studies.................................169 Developmental toxicity ....................................................... 171 Special studies ............................................................................ 176 Neurotoxicity....................................................................... 176 Toxicity of metabolites........................................................ 177 Effects on bile-duct hyperplasia .......................................... 177 Observations in humans..................................................................... 178 Comments.................................................................................................... 178 Toxicological evaluation ............................................................................. 180 References ................................................................................................... 183
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